Microcrystalline Tests
A microcrystalline test is a presumptive test in which there is a chemical reaction (precipitation reaction) between a substance and a reagent that yields a crystal formation that can be observed microscopically.
The major advantages of a microcrystalline test are: rapid and simple procedure, high sensitivity, can be conducted on unextracted samples, can be utilized to distinguish isomers of certain drugs, and crystals formed are actual crystals of the drug.
DART-TOF Mass Spectrometry (Preferred Method)
Direct analysis in real time (DART) is an open air ionization technique. The open air source allows sampling of solids, liquids, and gases through surface ionization of the test material. The ion source is coupled to an accurate time-of-flight mass spectrometer giving quick analysis of molecular ions with little to no sample preparation.